The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 15, 2022

Filed:

Sep. 07, 2018
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Aijun Wang, Sacramento, CA (US);

Kit Lam, Davis, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61L 27/22 (2006.01); C07K 14/78 (2006.01); A61L 27/16 (2006.01); A61L 27/18 (2006.01); A61L 27/38 (2006.01); C07K 7/64 (2006.01); C08L 27/18 (2006.01); C08L 67/04 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61L 27/22 (2013.01); A61L 27/16 (2013.01); A61L 27/18 (2013.01); A61L 27/3821 (2013.01); C07K 7/64 (2013.01); C07K 14/78 (2013.01); C08L 27/18 (2013.01); C08L 67/04 (2013.01); A61K 38/00 (2013.01); C08L 2203/02 (2013.01);
Abstract

The present invention provides scaffolds that include a polymer and a cyclic peptide ligand. The peptide ligand increases the attachment of endothelial cells and/or progenitor cells to the scaffold. The present invention also provides engineered tissues that include the provided scaffolds. The present invention also provides coatings that include a coating polymer and a cyclic peptide ligand. The present invention also provides methods of improving endothelialization and vascularization of endothelial cells and/or progenitor cells for tissue regeneration in a subject and of repairing bone defects in a subject, by implanting a provided scaffold.


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