The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 15, 2022

Filed:

Jun. 07, 2019
Applicant:

National Defense Medical Center, Taipei, TW;

Inventors:

Chih-Hung Wang, New Taipei, TW;

Ai-Ho Liao, Taipei, TW;

Hang-Kang Chen, New Taipei, TW;

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/69 (2017.01); A61K 33/243 (2019.01); A61P 35/00 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); A61K 41/00 (2020.01);
U.S. Cl.
CPC ...
A61K 47/6925 (2017.08); A61K 9/0009 (2013.01); A61K 9/5052 (2013.01); A61K 9/5089 (2013.01); A61K 33/243 (2019.01); A61K 41/0028 (2013.01); A61P 35/00 (2018.01);
Abstract

Disclosed herein is a method for treating a cancer, the method includes following operations. A pharmaceutical composition is administered to a subject in need. The pharmaceutical composition includes a medium and a plurality of cisplatin-loaded microbubbles dispersed in the medium. Each cisplatin-loaded microbubble includes a shell portion and a core portion. The shell portion includes a plurality of albumin molecules and a plurality of first cisplatin molecules covalently bonding to the albumin molecules. The core portion is surrounded by the shell portion, wherein the core portion includes a mixture of inert gas and a plurality of second cisplatin molecules. Ultrasound energy is then applied to a tumor of the subject to break the cisplatin-loaded microbubbles.


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