The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 15, 2022

Filed:

Oct. 15, 2018
Applicant:

Asclepius (Suzhou) Technology Company Group Co., Ltd., Suzhou, CN;

Inventors:

Huashun Li, Suzhou, CN;

Baolei Wang, Suzhou, CN;

Baoyong Ren, Suzhou, CN;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); C07K 14/705 (2006.01); C07K 19/00 (2006.01); C12N 15/09 (2006.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C12N 15/85 (2006.01); C12N 5/10 (2006.01); C07K 14/78 (2006.01); C07K 14/73 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 14/705 (2013.01); C07K 14/7051 (2013.01); C07K 14/70514 (2013.01); C07K 14/70517 (2013.01); C07K 14/70575 (2013.01); C07K 14/78 (2013.01); C07K 19/00 (2013.01); C12N 5/10 (2013.01); C12N 15/09 (2013.01); C12N 15/85 (2013.01);
Abstract

A chimeric antigen receptor (CAR) and a gene encoding the CAR. The CAR comprises an extracellular domain capable of binding to an antigen, a transmembrane domain, and intracellular immune co-stimulatory molecule, wherein the extracellular domain comprises a D2 domain of a Slit2 protein. A chimeric antibody-expressing cell, which introduces a gene encoding the CAR into a cell so as to express the CAR on the surface of the cell. The CAR or CAR-expressing cell can be used as a cell drug for the treatment of tumor diseases. By using the CAR for engineering cells, especially T cells, the engineered T cells can specifically recognize and kill tumors, and have higher tumoricidal activity.


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Li, Huashun. (2022). Slit2d2-chimeric antigen receptor and application thereof (U.S. Patent No. 11246888). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11246888

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