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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11243211 B1

PDFFull Text
Date of Patent:
Feb. 08, 2022

Filed:

Feb. 25, 2020

Methods and compositions for diagnosis and treatment of autoimmune disease secondary to multiple sclerosis by assessing genotypes associated with elevated il-21

Applicant:

Cambridge Enterprise Limited, Cambridge, GB;

Inventors:

Alasdair J. Coles, Cambridge, GB;

Joanne L. Jones, Cambridge, GB;

Alastair Compston, Cambridge, GB;

Assignee:

Cambridge Enterprise Limited, Cambridge, GB;

Attorneys:

Steptoe & Johnson LLP

Z. Ying Li

Wyan-Ching M. Lee

Primary Examiner:

G R Ewoldt

Int. Cl.
CPC ...
G01N 33/564 (2006.01); G01N 33/68 (2006.01); C12Q 1/6883 (2018.01); C12Q 1/6827 (2018.01); C12N 15/10 (2006.01); A61P 25/00 (2006.01); A61P 37/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6869 (2013.01); A61P 25/00 (2018.01); A61P 37/00 (2018.01); C12N 15/1075 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6883 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/172 (2013.01); G01N 2800/285 (2013.01); G01N 2800/52 (2013.01);
Abstract

The invention provides methods of diagnosing and treating multiple sclerosis (MS) patients, including methods of identifying and treating multiple sclerosis patients who are at increased risk of developing a secondary autoimmune disease following lymphocyte depletion, caused, e.g., by treatment with an anti-CD52 antibody. The increased risk may be linked to certain single nucleotide polymorphism genotypes that are indicative of elevated IL-21 levels. Also embraced are methods of selecting treatment regimens for MS patients, and reagents useful in the above methods.

Find Patent Forward Citations

Coles, Alasdair. (2022). Methods and compositions for diagnosis and treatment of autoimmune disease secondary to multiple sclerosis by assessing genotypes associated with elevated il-21 (U.S. Patent No. 11243211). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11243211

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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