The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2022
Filed:
Feb. 02, 2018
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Kevin V. Morris, Sierra Madre, CA (US);
Roslyn Ray, Monrovia, CA (US);
Assignee:
CITY OF HOPE, Duarte, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/113 (2010.01); A61P 3/06 (2006.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1138 (2013.01); A61K 31/713 (2013.01); A61P 3/06 (2018.01); C12N 2310/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3341 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/32 (2013.01);
Abstract
Provided herein are, inter alia, compositions and methods for the treatment of hypercholesterolemia. The compositions include double-stranded and single-stranded RNAs capable of repressing IncRNA and concomitantly increasing LDLR activation. The compositions are useful for activating LDLR in liver cells.