The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2022
Filed:
Nov. 13, 2017
Applicant:
Shanghai Unicar-therapy Bio-medicine Technology Co., Ltd, Shanghai, CN;
Inventors:
Assignee:
SHANGHAI UNICAR-THERAPY BIO-MEDICINE TECHNOLOGY CO., LTD, Shanghai, CN;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 15/86 (2006.01); A61K 35/17 (2015.01); C12N 15/66 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1138 (2013.01); A61K 35/17 (2013.01); C07K 14/70521 (2013.01); C12N 15/66 (2013.01); C12N 15/86 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/32 (2013.01); C12N 2330/51 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/15051 (2013.01); C12N 2740/16043 (2013.01);
Abstract
Provided are a human PD-1 knockdown siRNA, a recombinant expression CAR-T vector, a preparation method thereof, and an application of the same. A PD-1 knockdown siRNA expression cassette and an siRNA expression product thereof can be applied to a CAR-T therapy of multiple myeloma (MM) for eliminating or alleviating a tumor immune escape mechanism, and in the suppression of an immune escape mechanism in a CAR-T therapy of a tumor, such as pancreatic cancer, brain glioma, and myeloma.