The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2022
Filed:
Feb. 28, 2020
Applicants:
Nbe-therapeutics Ag, Basel, CH;
The Scripps Research Institute, La Jolla, CA (US);
Inventors:
Christoph Rader, Jupiter, FL (US);
Haiyong Peng, Jupiter, FL (US);
Roger Beerli, Adlikon, CH;
Lorenz Waldmeier, Basel, CH;
Ulf Grawunder, Hersberg, CH;
Assignees:
NBE-Therapeutics AG, Basel, CH;
The Scripps Research Institute, La Jolla, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61K 47/68 (2017.01); C07K 14/725 (2006.01); A61K 47/69 (2017.01); C07K 14/705 (2006.01); C12N 9/12 (2006.01); A61P 35/02 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 47/6809 (2017.08); A61K 47/6849 (2017.08); A61K 47/6889 (2017.08); A61K 47/6903 (2017.08); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07K 14/705 (2013.01); C07K 14/7051 (2013.01); C12N 9/12 (2013.01); C12Y 207/10001 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/73 (2013.01); C07K 2317/90 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01);
Abstract
The invention provides antibodies, antibody drug conjugates, antibody-based fragments or antibody fragments (antigen-binding fragments), as well as antibody drug conjugates (ADCs) and chimeric antigen receptors (CARs), that specifically recognize human ROR1 and related compositions. Also provided in the invention are methods of using such antibodies in various diagnostic and therapeutic applications.