The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 08, 2022

Filed:

Jul. 16, 2020
Applicant:

Sanofi, Paris, FR;

Inventors:

Gary Shapiro, Arlington, MA (US);

Kevin Brower, Holliston, MA (US);

Patrick Finn, Franklin, MA (US);

Richard C. Gregory, Framingham, MA (US);

Rao Koduri, Shrewsbury, MA (US);

Feng Liu, San Diego, CA (US);

Natalia Malkova, Needham, MA (US);

Parminder Mankoo, Foster City, CA (US);

Jack R. Pollard, Acton, MA (US);

Huawei Qiu, Westborough, MA (US);

Joachim Theilhaber, Cambridge, MA (US);

Christopher Winter, Swampscott, MA (US);

Marcella Yu, Fremont, CA (US);

Assignee:

SANOFI, Paris, FR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/22 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); C07K 16/30 (2013.01); C07K 16/32 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/52 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract

The invention provides an improved pan-TGF-β antibody for treatment of conditions that are mediated by TGF-β, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.


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