The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2022
Filed:
Apr. 24, 2020
Genentech, Inc., South San Francisco, CA (US);
Nicole Blaquiere, South San Francisco, CA (US);
Peter Dragovich, South San Francisco, CA (US);
Lewis J. Gazzard, South San Francisco, CA (US);
Thomas Pillow, South San Francisco, CA (US);
Steven T. Staben, South San Francisco, CA (US);
Binqing Wei, South San Francisco, CA (US);
Jianfeng Xin, Beijing, CN;
Genentech, Inc., South San Francisco, CA (US);
Abstract
The present disclosure relates to bifunctional compounds, which can be used as modulators of targeted ubiquitination. In particular, the present disclosure is directed to compounds which contain on one end a VHL ligand moiety, which binds to the VHL E3 ubiquitin ligase, and on the other end a moiety that binds a target protein such that degradation of the target protein/polypeptide is effectuated. Also disclosed are VHL ligands.