The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2022
Filed:
Nov. 30, 2017
Applicant:
Texas Children's Hospital, Houston, TX (US);
Inventors:
Ananth Annapragada, Houston, TX (US);
Eric A. Tanifum, Houston, TX (US);
Assignee:
TEXAS CHILDREN'S HOSPITAL, Houston, TX (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); A61K 51/04 (2006.01); A61K 49/10 (2006.01); A61K 49/12 (2006.01); A61K 49/18 (2006.01); A61K 51/12 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0453 (2013.01); A61K 49/10 (2013.01); A61K 49/124 (2013.01); A61K 49/1812 (2013.01); A61K 51/0491 (2013.01); A61K 51/1234 (2013.01);
Abstract
Readily available hydrophilic and small organofluorine moieties were condensed via 'click chemistry' to generate nonionic hydrophilic fluorinated molecules with uniqueF MR signatures. These were used to fabricate stable liposome formulations for imaging various tissue types. This approach was tailored to exploit the broad spectrum of organicF molecular species and to generate probes with distinctF MRI signatures for simultaneous assessment of multiple molecular targets within the same target volume.