The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2022
Filed:
Aug. 22, 2019
Applicant:
Korea University Research and Business Foundation, Seoul, KR;
Inventors:
Jong Seung Kim, Seongnam-si, KR;
Amit Sharma, Seoul, KR;
Min Goo Lee, Seoul, KR;
Miae Won, Seoul, KR;
Jin Yong Lee, Suwon-si, KR;
Sung-Gil Chi, Goyang-si, KR;
Jonathan L. Sessler, Austin, TX (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/55 (2017.01); A61K 31/704 (2006.01);
U.S. Cl.
CPC ...
A61K 47/55 (2017.08); A61K 31/704 (2013.01);
Abstract
Disclosed is an anticancer prodrug that disturbs energy metabolism in cancer cells to overcome drug resistance. The anticancer prodrug has a structure including a pyruvate dehydrogenase kinase (PDK) inhibitor moiety, a mitochondrial targeting group, and an anthracycline moiety reversibly connected to the PDK inhibitor moiety and the targeting group.