The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 08, 2022

Filed:

May. 09, 2018
Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

David Weiner, Merion, PA (US);

Matthew P. Morrow, Bala Cynwyd, PA (US);

Jian Yan, Wallingford, PA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); C12P 21/02 (2006.01); C07K 14/54 (2006.01); A61K 38/20 (2006.01); A61K 39/39 (2006.01); A61K 39/00 (2006.01); A61K 39/245 (2006.01); C12N 7/00 (2006.01); A61K 39/29 (2006.01); A61K 41/00 (2020.01); A61K 39/395 (2006.01); C12N 5/10 (2006.01); C12N 7/02 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39 (2013.01); A61K 38/20 (2013.01); A61K 38/208 (2013.01); A61K 38/2086 (2013.01); A61K 39/0005 (2013.01); A61K 39/00114 (2018.08); A61K 39/245 (2013.01); A61K 39/292 (2013.01); A61K 41/00 (2013.01); C07K 14/5434 (2013.01); C12N 7/00 (2013.01); A61K 2039/525 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55538 (2013.01); C12N 2510/00 (2013.01); C12N 2710/16034 (2013.01); C12N 2730/10134 (2013.01); C12N 2730/10171 (2013.01);
Abstract

Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.


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