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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11241450 B1

PDFFull Text
Date of Patent:
Feb. 08, 2022

Filed:

Apr. 15, 2020

Uridine diphosphate derivatives, prodrugs, compositions and uses thereof

Applicant:

Tufts University, Boston, MA (US);

Inventors:

Philip G. Haydon, Boston, MA (US);

Jinbo Lee, Andover, MA (US);

Assignee:

Tufts University, Boston, MA (US);

Attorneys:

Morse, Barnes-Brown & Pendleton, P.C.

Lisa M. Warren, Esq.

Erin E. Bryan, Esq.

Primary Examiner:

Layla D Berry

Int. Cl.
CPC ...
A61K 31/7072 (2006.01); A61K 31/7052 (2006.01); A61K 31/706 (2006.01); A61K 31/7068 (2006.01); A61K 31/7064 (2006.01); A61K 31/7042 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 405/04 (2006.01); C07H 19/067 (2006.01); C07F 9/6558 (2006.01); C07F 9/6574 (2006.01); C07F 9/09 (2006.01); C07F 9/22 (2006.01); C07H 19/06 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7072 (2013.01); A61K 9/0019 (2013.01); A61K 31/706 (2013.01); A61K 31/7042 (2013.01); A61K 31/7052 (2013.01); A61K 31/7064 (2013.01); A61K 31/7068 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07F 9/09 (2013.01); C07F 9/22 (2013.01); C07F 9/65586 (2013.01); C07F 9/65742 (2013.01); C07F 9/65744 (2013.01); C07H 19/06 (2013.01); C07H 19/067 (2013.01);
Abstract

This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs of UDP derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs for treating various disorders including, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma, and inflammatory conditions, e.g., psoriasis and rheumatoid arthritis.

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