The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Jun. 30, 2015
Bio-rad Europe Gmbh, Basel, CH;
Centre National DE LA Recherche Scientifique, Paris, FR;
Universite DE Montpellier, Montpellier, FR;
Chu Montpellier, Montpellier, FR;
Claude Granier, Istres, FR;
Franck Molina, Les Matelles, FR;
Nicolas Salvetat, Montpellier, FR;
Laurence Molina, Las Matelles, FR;
Randa Siala, Brussels, BE;
Eric Renard, Saint Clement de Riviere, FR;
BIO-RAD EUROPE GMBH, Basel, CH;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris, FR;
UNIVERSITÉ DE MONTPELLIER, Montpellier, FR;
CHU MONPELLIER, Montpellier, FR;
Abstract
The present invention concerns a method for the in vitro detection of an increased risk of diabetic nephropathy in a subject suffering from diabetes and being normoalbuminuric. Another aspect of the invention pertains to a method for the in vitro identification of a marker for prediction of diabetic nephropathy. Finally, the invention concerns a kit comprising means for detecting at least two proteins selected from the group consisting of heparan sulfate proteoglycan core protein or fragments thereof, carbonic anhydrase 1, prothrombin or fragments thereof, tetranectin, CD59 glycoprotein, plasma serine protease inhibitor, mannan-binding lectin serine protease 2 or isoforms thereof, antithrombin-III, alpha-1-antitrypsin, collagen alpha-1(I) chain, alpha-enolase, histone H2B type 1-O, glutaminyl-peptide cyclotransferase, protein AMBP and zinc-alpha-2-glycoprotein.