The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Jun. 26, 2019
Applicant:
St. Jude Children's Research Hospital, Memphis, TN (US);
Inventors:
J. Paul Taylor, Memphis, TN (US);
Peiguo Yang, Memphis, TN (US);
Wenwei Lin, Memphis, TN (US);
Taosheng Chen, Memphis, TN (US);
Assignee:
ST. JUDE CHILDREN'S RESEARCH HOSPITAL, Memphis, TN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/64 (2006.01); G01N 33/573 (2006.01);
U.S. Cl.
CPC ...
G01N 33/573 (2013.01); G01N 21/6428 (2013.01); G01N 2021/6441 (2013.01); G01N 2333/914 (2013.01); G01N 2500/02 (2013.01);
Abstract
A method of identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) is provided, which includes determining whether a compound modulates the interaction between the N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and FGDF peptide of ubiquitin specific protease 10 (USP10) or non-structural protein 3 (nsP3).