The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Nov. 02, 2018
Applicant:
Research Development Foundation, Carson City, NV (US);
Inventors:
Brent Iverson, Austin, TX (US);
George Georgiou, Austin, TX (US);
Joseph Desautelle, Austin, TX (US);
Joseph Taft, Austin, TX (US);
Assignee:
Research Development Foundation, Carson City, NV (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/48 (2006.01); C12N 15/10 (2006.01); C12N 9/12 (2006.01); C12N 15/81 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/485 (2013.01); C12N 9/12 (2013.01); C12N 15/10 (2013.01); C12N 15/102 (2013.01); C12N 15/1037 (2013.01); C12N 15/81 (2013.01); C12Y 207/10002 (2013.01); C07K 2319/01 (2013.01); C07K 2319/04 (2013.01);
Abstract
Provided are methods for the identification of mutant kinases that are resistant to inhibition by a kinase inhibitor. In some embodiments, the methods may be used to assess a test compound or kinase inhibitor for the risk of the development of resistance in vivo, e.g., during clinical administration to treat a disease such as a cancer.