The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Apr. 30, 2015
Applicant:
Jiangsu Nuo-beta Pharmaceutical Technology Co., Ltd., Jiangsu, CN;
Inventors:
Fude Huang, Shanghai, CN;
Xiao Zhang, Shanghai, CN;
Wenan Wang, Shanghai, CN;
Haiyan Liu, Shanghai, CN;
Assignee:
Jiangsu Nuo-Beta Pharmaceutical Technology Co. Ltd., Jiangsu, CN;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61P 25/28 (2006.01); C12Q 1/02 (2006.01); G01N 33/68 (2006.01); C07K 14/47 (2006.01); A01K 67/033 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/025 (2013.01); C07K 14/4711 (2013.01); G01N 33/6896 (2013.01); A01K 67/0339 (2013.01); A01K 2227/706 (2013.01); A01K 2267/0312 (2013.01); C07K 2319/02 (2013.01); G01N 2800/2821 (2013.01);
Abstract
Disclosed is the use of genetic means or a related inhibitor to inhibit and down-regulate the amount of PI4KIIIα protein, RBO/EFR3/EFR3A/EFR3B membrane proteins, TTC7 protein and membrane protein complexes formed by said proteins, or related enzyme activity to promote Aβ secretion by neuronal cells, reduce Aβ accumulation within neurons, and thereby reduce AD model fruit fly and mouse nerve dysfunction.