The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
May. 21, 2018
Applicant:
Ramot AT Tel-aviv University Ltd., Tel Aviv, IL;
Inventors:
Tamir Tuller, Herzeliya Pituach, IL;
Hadas Zur, Tel Aviv Jaffa, IL;
Rachel Cohen-Kupiec, Tel Aviv, IL;
Assignee:
RAMOT AT TEL-AVIV UNIVERSITY LTD., Tel Aviv, IL;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/67 (2006.01); C12Q 1/6809 (2018.01); C12N 15/79 (2006.01);
U.S. Cl.
CPC ...
C12N 15/67 (2013.01); C12N 15/79 (2013.01); C12Q 1/6809 (2013.01); C12N 2800/22 (2013.01);
Abstract
Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.