The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Dec. 21, 2017
Applicant:
The U.s.a., As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventors:
Dimiter S. Dimitrov, Frederick, MD (US);
Weizao Chen, Frederick, MD (US);
Terry J. Fry, Aurora, CO (US);
Christopher Chien, Falls Church, VA (US);
Haiying Qin, Bethesda, MD (US);
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/395 (2006.01); G01N 33/53 (2006.01); A61K 47/69 (2017.01); A61K 47/68 (2017.01); A61P 35/02 (2006.01); A61P 35/04 (2006.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); C07K 16/46 (2006.01); G01N 33/577 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); A61K 47/6849 (2017.08); A61K 47/6929 (2017.08); A61P 35/00 (2018.01); A61P 35/02 (2018.01); A61P 35/04 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70578 (2013.01); C07K 16/468 (2013.01); G01N 33/577 (2013.01); C07K 2317/21 (2013.01); C07K 2317/31 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01);
Abstract
Human monoclonal antibodies that specifically bind Fms-like tyrosine kinase 3 (FLT3) are described. Chimeric antigen receptors (CARs) and other antibody conjugates that include the FLT3-specific monoclonal antibodies are also described. Methods for the diagnosis and treatment of FLT3-associated cancer, such as acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML), are further described.