The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Feb. 10, 2017
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Fan Pan, Baltimore, MD (US);
Duojia Pan, Dallas, TX (US);
Drew M. Pardoll, Brookeville, MD (US);
Joseph Barbi, East Amherst, NY (US);
Juan Fu, Lutherville, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/22 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61K 31/7105 (2006.01); A61K 38/17 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61K 31/7105 (2013.01); A61K 38/179 (2013.01); A61K 39/3955 (2013.01); A61P 17/06 (2018.01); A61P 19/02 (2018.01); A61P 35/00 (2018.01); A61K 2039/505 (2013.01); A61K 2039/577 (2013.01);
Abstract
The present invention relates to compositions and methods for treating cancer by targeting the Activin signaling pathway. In certain embodiments, combining Activin blockade with immunomodulation alters regulatory T (Treg) cell-mediated immune regulation and treats cancer.