The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 01, 2022

Filed:

Oct. 26, 2017
Applicant:

Celltrion Inc., Incheon, KR;

Inventors:

Joon Won Lee, Incheon, KR;

Won Yong Han, Incheon, KR;

Su Jung Kim, Incheon, KR;

Jun Seok Oh, Incheon, KR;

So Young Kim, Incheon, KR;

Kwang Woo Kim, Incheon, KR;

Yeon Kyeong Shin, Incheon, KR;

Assignee:

Celltrion Inc., Incheon, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 14/705 (2006.01); A61K 9/08 (2006.01); A61K 47/02 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); A61K 47/12 (2006.01); A61K 38/16 (2006.01); A61K 38/19 (2006.01); A61K 38/17 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70578 (2013.01); A61K 9/08 (2013.01); A61K 38/16 (2013.01); A61K 38/1774 (2013.01); A61K 38/191 (2013.01); A61K 39/39591 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); C07K 2319/30 (2013.01);
Abstract

Disclosed is a stable pharmaceutical formulation, comprising a fusion protein in which the extracellular ligand-binding domain of a human p75 tumor necrosis factor receptor is fused to the Fc domain of human IgG and a succinate buffering agent, without comprising a stabilizer. The stable pharmaceutical formulation enables the long-term storage of the TNFR-Fc fusion protein formulation and can exhibit superior storage stability without the need for demanding storage conditions, and is a simple formulation because no stabilizer is comprised therein and is thus more economical than other stabilizer-comprising formulations.


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