The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Jun. 19, 2019
Applicant:
Carnegie Mellon University, Pittsburgh, PA (US);
Inventors:
Danith H. Ly, Pittsburgh, PA (US);
Suresh Kumar Gopalsamy, Tamilnadu, IN;
Arunava Manna, Pittsburgh, PA (US);
Assignee:
Carnegie Mellon University, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2018.01); C12Q 1/6809 (2018.01); C07D 239/47 (2006.01); C07D 239/54 (2006.01); C07D 251/16 (2006.01); C07D 471/04 (2006.01); C07D 475/08 (2006.01); C07D 487/04 (2006.01); C07D 487/16 (2006.01); C07H 1/06 (2006.01); G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
C07K 14/003 (2013.01); C07D 239/47 (2013.01); C07D 239/54 (2013.01); C07D 251/16 (2013.01); C07D 471/04 (2013.01); C07D 475/08 (2013.01); C07D 487/04 (2013.01); C07D 487/16 (2013.01); C07H 1/06 (2013.01); C07H 21/04 (2013.01); C12Q 1/6809 (2013.01); G01N 33/5308 (2013.01);
Abstract
Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (γPNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.