The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Dec. 20, 2019
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Nuria A. Tamayo, Newbury Park, CA (US);
Abhisek Banerjee, Karnataka, IN;
Jian Jeffrey Chen, Camarillo, CA (US);
Jonathan Dante Low, Reseda, CA (US);
Ana Elena Minatti, Los Angeles, CA (US);
Matthew Paul Bourbeau, Woodland Hills, CA (US);
Assignee:
AMGEN INC., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 401/12 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 419/14 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 401/12 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 419/14 (2013.01); C07D 491/107 (2013.01);
Abstract
Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.