The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Apr. 17, 2019
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Michael Holinstat, Ann Arbor, MI (US);
Reheman Adili, Ypsilanti, MI (US);
Andrew White, Ann Arbor, MI (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 311/44 (2006.01); C07D 209/40 (2006.01); A61P 7/02 (2006.01);
U.S. Cl.
CPC ...
C07C 311/44 (2013.01); A61P 7/02 (2018.01); C07D 209/40 (2013.01); C07C 2601/02 (2017.05);
Abstract
Disclosed herein are small molecule inhibitors of 12(S)-Lipoxygenase (12-LOX), and methods of using the small molecules to inhibit 12-LOX activation and to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.