The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 01, 2022

Filed:

Jul. 12, 2018
Applicant:

Varian Medical Systems, Inc., Palo Alto, CA (US);

Inventors:

Hongxia Zeng, Maple Grove, MN (US);

Bruce R. Forsyth, Hanover, MN (US);

Hong Cao, Maple Grove, MN (US);

Matthew R. DeWitt, Charlottesville, VA (US);

Heidi Schwanz, Maple Grove, MN (US);

Assignee:

Varian Medical Systems, Inc., Palo Alto, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61L 24/02 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61L 24/00 (2006.01); A61L 24/04 (2006.01); A61L 24/06 (2006.01); A61M 25/00 (2006.01);
U.S. Cl.
CPC ...
A61L 24/02 (2013.01); A61K 9/0019 (2013.01); A61K 9/1617 (2013.01); A61K 9/1623 (2013.01); A61L 24/0015 (2013.01); A61L 24/0031 (2013.01); A61L 24/0042 (2013.01); A61L 24/043 (2013.01); A61L 24/046 (2013.01); A61L 24/06 (2013.01); A61L 2300/604 (2013.01); A61L 2300/608 (2013.01); A61L 2400/06 (2013.01); A61L 2420/06 (2013.01); A61L 2420/08 (2013.01); A61L 2430/36 (2013.01); A61M 25/0097 (2013.01);
Abstract

In some aspects, the disclosure pertains to injectable particles that contain at least one pH-altering agent that is configured to be released from the injectable particles in vivo, upon embolization of an intratumoral artery of a tumor with the injectable particles. In certain instances, the pH-altering agent may be a basic agent having a pH value of 7.5, a buffering agent having a pKa value of 7.6 or more, or both. Other aspects of the disclosure pertain to preloaded containers containing such injectable particles and methods of using such injectable particles.


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