The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Apr. 12, 2018
Applicant:
Industry-university Cooperation Foundation Hanyang University, Seoul, KR;
Inventors:
Chae Ok Yun, Seoul, KR;
Youjin Na, Seoul, KR;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/761 (2015.01); A61K 38/00 (2006.01); A61K 38/10 (2006.01); A61K 47/60 (2017.01); A61P 35/00 (2006.01); C12N 15/861 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0041 (2013.01); A61K 35/761 (2013.01); A61K 38/00 (2013.01); A61K 47/60 (2017.08); A61P 35/00 (2018.01);
Abstract
The present invention relates to an adenovirus complex which can be utilized for gene delivery and gene therapy by targeting neurotensin receptors. The complex of the present invention has an excellent antitumor effect because of a high intracellular gene transfer efficiency and target specificity by neurotensin receptor-specific binding, has little hepatotoxicity and immunogenicity, forms a stable complex, has low immunogenicity, and thus has a low loss in blood even in an in vivo environment. Therefore, the complex of the present invention can be effectively used for gene therapy.