The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Dec. 01, 2016
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Thomas D. Wang, Ann Arbor, MI (US);
Supang Khondee, Phayao, TH;
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/69 (2017.01); C08G 69/40 (2006.01); C08G 69/10 (2006.01); C08G 81/00 (2006.01); A61K 9/107 (2006.01); A61K 47/62 (2017.01); A61K 47/60 (2017.01); A61K 47/54 (2017.01); A61P 35/00 (2006.01); A61K 31/436 (2006.01); C08G 65/334 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6907 (2017.08); A61K 9/1075 (2013.01); A61K 31/436 (2013.01); A61K 47/554 (2017.08); A61K 47/60 (2017.08); A61K 47/62 (2017.08); A61P 35/00 (2018.01); C08G 65/3348 (2013.01); C08G 69/10 (2013.01); C08G 69/40 (2013.01); C08G 81/00 (2013.01);
Abstract
The present invention relates to micelle drug carriers and methods of using the micelles to deliver drugs to target cells. The micelles are useful, for example, for carrying and targeting drugs for the treatment of cancer to cancer cells. As one example, the disclosure provides pegylated octadecyl lithocholate micelles that are labeled with a peptide ligand for colorectal neo-plasia and that carry the small molecule mTOR inhibitor rapamycin to colorectal cancer cells.