The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 01, 2022

Filed:

Aug. 21, 2020
Applicants:

Pdx Pharmaceuticals, Inc., Portland, OR (US);

Oregon Health & Science University, Portland, OR (US);

Inventors:

Wassana Yantasee, Lake Oswego, OR (US);

Amanda Lund, Portland, OR (US);

Worapol Ngamcherdtrakul, Portland, OR (US);

Moataz Reda, Portland, OR (US);

Assignees:

Oregon Health & Science University, Portland, OR (US);

PDX Pharmaceuticals, Inc., Portland, OR (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 31/7105 (2006.01); A61K 39/39 (2006.01); A61K 9/16 (2006.01); A61P 35/00 (2006.01); A61K 9/00 (2006.01); A61K 31/519 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39 (2013.01); A61K 9/0014 (2013.01); A61K 9/0021 (2013.01); A61K 9/1676 (2013.01); A61K 31/519 (2013.01); A61K 31/7105 (2013.01); A61P 35/00 (2018.01); C12N 15/113 (2013.01); C12N 15/1135 (2013.01); A61K 2039/55561 (2013.01); C12N 2310/141 (2013.01); C12N 2320/31 (2013.01); C12N 2320/35 (2013.01);
Abstract

Disclosed herein are immunotherapeutic constructs comprising a delivery particle, at least one adjuvant, and one or more therapeutic agents/compounds that cause antigen release and/or modulate immunosuppressive tumor microenvironment. These immunotherapeutic constructs create adaptive immunity or anti-cancer immune response(s) that can be used, for instance, to prevent and treat broad types of cancer. Further disclosed are uses of the immunotherapeutic constructs, including to prevent and treat cancer in humans and animals.


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