The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 01, 2022

Filed:

Jun. 29, 2018
Applicants:

Los Alamos National Security, Llc, Los Alamos, NM (US);

Oxford University Innovation Limited, Oxford, GB;

Inventors:

Bette T. M. Korber, Los Alamos, NM (US);

Tomas Hanke, Oxford, GB;

Andrew McMichael, Oxford, GB;

Assignees:

Triad National Security, LLC, Los Alamos, NM (US);

Isis Innovation Limited, Oxford, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/21 (2006.01); A61K 39/12 (2006.01); C07K 14/16 (2006.01); C07K 14/005 (2006.01);
U.S. Cl.
CPC ...
A61K 39/21 (2013.01); A61K 39/12 (2013.01); C07K 14/005 (2013.01); C07K 14/161 (2013.01); C07K 14/162 (2013.01); C12N 2740/16034 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16222 (2013.01);
Abstract

Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.


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