The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Mar. 14, 2014
Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment
Polaris Group, Grand Cayman, KY;
Robert Almassy, Vista, CA (US);
Richard E. Showalter, El Cajon, CA (US);
James A. Thomson, San Diego, CA (US);
Wes Sisson, San Diego, CA (US);
Wei-Jong Shia, San Diego, CA (US);
Li-Chang Chen, San Diego, CA (US);
Yang Lee, San Diego, CA (US);
Polaris Group, Grand Cayman, KY;
Abstract
The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20 (pegylated ADI derived from), but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer.