The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 01, 2022

Filed:

Sep. 03, 2019
Applicant:

Multistars Biotechnology Company Limited, Taoyuan, TW;

Inventors:

Po-I Wu, Taoyuan, TW;

Chih-Jung Chang, Taoyuan, TW;

Yu-Ling Tsai, Taoyuan, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/02 (2006.01); A61K 45/00 (2006.01); A61K 35/742 (2015.01); A61P 13/12 (2006.01);
U.S. Cl.
CPC ...
A61K 35/742 (2013.01); A61P 13/12 (2018.01);
Abstract

The present invention provides a method of improving the phenomenon of the glomerular sclerosis and mononuclear leukocyte infiltration around renal tissues, and increasing the renal function by administering the probiotic bacterium of ato a subject in need to inhibit the occurrence of chronic kidney disease. Thecan also effectively modulate the gene expression level of MCP-1, IL-1β, COL3A, COL6A1, ACAA2, PPAR-γ, CPT1, and PGC-1α in kidney tissues to reduce kidney inflammation and renal fibrosis and enhance the mitochondria activity of kidney cells. Therefore, theof the present invention can be utilized in pharmaceutical compositions for inhibiting or treating chronic kidney diseases.


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