The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Jan. 05, 2017
Osaka University, Osaka, JP;
National University Corporation Tokyo Medical and Dental University, Tokyo, JP;
National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, JP;
Masayuki Nakamori, Osaka, JP;
Hideki Mochizuki, Osaka, JP;
Satoshi Obika, Osaka, JP;
Takanori Yokota, Tokyo, JP;
Tetuya Nagata, Tokyo, JP;
Yuya Kasahara, Osaka, JP;
OSAKA UNIVERSITY, Osaka, JP;
NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, Tokyo, JP;
NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION, Osaka, JP;
Abstract
The present invention can provide a nucleic acid medicine which has a higher effect and a more prolonged effect of inhibiting the expression of α-synudein can be provided. Disclosed is the oligonucleotide or a pharmacologically acceptable salt thereof, the oligonucleotide containing at least one nucleoside structure represented by Formula (I): (where each of Base and A are defined substituent or structure), can bind to an α-synudein gene, has activity for inhibiting expression of the α-synudein gene, and is complementary to the α-synudein gene, and the oligonucleotide has a length of twelve to twenty bases.