The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Sep. 14, 2017
Applicant:
University of Dundee, Dundee, GB;
Inventors:
Alessio Ciulli, Dundee, GB;
Andrea Testa, Dundee, GB;
Assignee:
University of Dundee, Dundee, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/00 (2006.01); A61K 31/551 (2006.01); A61K 47/54 (2017.01); A61K 47/55 (2017.01); A61K 31/4709 (2006.01); A61K 45/06 (2006.01); C07D 207/46 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 495/14 (2006.01); C07D 207/16 (2006.01); C07K 5/062 (2006.01); C07K 5/087 (2006.01); A61K 31/427 (2006.01);
U.S. Cl.
CPC ...
A61K 31/551 (2013.01); A61K 31/427 (2013.01); A61K 31/4709 (2013.01); A61K 45/06 (2013.01); A61K 47/545 (2017.08); A61K 47/55 (2017.08); A61K 47/555 (2017.08); C07D 207/16 (2013.01); C07D 207/46 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 495/14 (2013.01); C07K 5/06034 (2013.01); C07K 5/0812 (2013.01); C07B 2200/07 (2013.01);
Abstract
There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitor compounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.