The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2022
Filed:
Mar. 20, 2018
Inserm (Institute National DE LA Santé ET DE LA Recherche Médicale), Paris, FR;
Université Paris Descartes, Paris, FR;
Assistance Publique-hôpitaux DE Paris (Aphp), Paris, FR;
Université Paris Diderot—paris 7, Paris, FR;
Pierre-Emmanuel Rautou, Paris, FR;
Chantal Boulanger-Robert, Paris, FR;
INSERM (Institut National de la Santé et de la Recherche Médicale), Paris, FR;
Université Paris Descartes, Paris, FR;
Assistance Publique Hôpitaux de Paris (APHP), Paris, FR;
UniversitéParis Diderot—Paris 7, Paris, FR;
Abstract
Plasma levels of different sub-populations of microvesicles (endothelial, leukocyte, platelet and hepatocyte) were measured by flow cytometry or ELISA/filtration on blood samples from 125 patients with cirrhosis, for which 36 of them were diagnosed with HCC at inclusion. The inventors show that the levels of microvesicles of endothelial origin (CD62E+) could predict the occurrence of HCC in patients with cirrhosis. Therefore the present invention relates to a method for determining whether a patient suffering from cirrhosis is at risk of having or developing hepatocellular carcinoma comprising determining the level of endothelial-derived microvesicles (e.g. by flow cytometry) in a blood sample obtained from the patient.