The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2022
Filed:
May. 19, 2015
Shimadzu Corporation, Kyoto, JP;
National Center for Geriatrics and Gerontology, Obu, JP;
Naoki Kaneko, Kyoto, JP;
Katsuhiko Yanagisawa, Ryugasaki, JP;
Shimadzu Corporation, Kyoto, JP;
National Center for Geriatrics and Gerontology, Aichi, JP;
Abstract
Provided are a biomarker for evaluating a cerebral Aβ accumulation state using an amyloid precursor protein (APP)-derived peptide in a living body-derived sample as an index, and a method for analysis thereof. A living body-derived sample derived from a test subject is measured, and at least one ratio selected from the group consisting of APP669-711/APP672-713 (Aβ1-42); APP672-709 (Aβ1-38)/APP672-713 (Aβ1-42); APP674-711 (Aβ3-40)/APP672-713 (Aβ1-42); APP672-710 (Aβ1-39)/APP672-713 (Aβ1-42); APP672-711 (Aβ1-40)/APP672-713 (Aβ1-42); and APP672-711 (OxAβ1-40)/APP672-713 (Aβ1-42) is calculated, and when each of the ratios of the test subject is higher than each of standard levels which are ratios of a person having normal cognitive function NC− who is negative for cerebral Aβ accumulation, an accumulation amount of cerebral Aβ of the test subject is determined as larger than an accumulation amount of cerebral Aβ of the person having normal cognitive function NC−.