The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 25, 2022

Filed:

Sep. 18, 2020
Applicant:

Gen-probe Incorporated, San Diego, CA (US);

Inventors:

David Buse, San Diego, CA (US);

David Howard Combs, San Diego, CA (US);

Norbert D. Hagen, Carlsbad, CA (US);

David Opalsky, San Diego, CA (US);

Bruce Richardson, Los Gatos, CA (US);

Anita Prasad, Los Gatos, CA (US);

Keith Moravick, Los Gatos, CA (US);

Tyler Moore, Los Gatos, CA (US);

Byron J. Knight, San Diego, CA (US);

Assignee:

GEN-PROBE INCORPORATED, San Diego, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/686 (2018.01); B01L 7/00 (2006.01); G01N 21/64 (2006.01); B01L 9/06 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/686 (2013.01); B01L 7/52 (2013.01); G01N 21/6452 (2013.01); B01L 9/06 (2013.01); B01L 2200/141 (2013.01); B01L 2200/142 (2013.01); B01L 2300/042 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0829 (2013.01); B01L 2300/0851 (2013.01); B01L 2300/1822 (2013.01); G01N 2021/6482 (2013.01); G01N 2021/6484 (2013.01);
Abstract

Receptacles containing a reaction mixture are transported to receptacle wells of a thermally conductive receptacle holder, and the temperature of the holder is cycled with a thermoelectric device situated between a support and a first side of the holder while a first force is applied onto a second side of the holder. Optical communication between each well and an excitation signal source and an emission signal detector is established to determine whether an emission signal is emitted from any of the receptacles during temperature cycling as an indication of the presence of a target nucleic acid. The thermoelectric device may be situated between an upright portion of the support and the first side of the holder. A second force may be applied onto a top end of each receptacle in the holder by a cover moveable with respect to the receptacles between an open position and a closed position.


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