The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 25, 2022

Filed:

Mar. 07, 2018
Applicants:

Oxford University Innovation Limited, Oxford, GB;

U.s. Dept. of Health and Human Services (Dhhs), U.s. Government, Bethesda, MD (US);

Inventors:

Richard Lewis Veech, Rockville, MD (US);

Michael Todd King, Gaithersburg, MD (US);

Kieran Clarke, Oxford, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P 7/26 (2006.01); C12P 7/62 (2006.01); C07C 69/675 (2006.01); C07C 59/01 (2006.01); C07C 51/09 (2006.01); C08G 63/06 (2006.01); C07H 13/04 (2006.01);
U.S. Cl.
CPC ...
C12P 7/625 (2013.01); C07C 51/09 (2013.01); C07C 69/675 (2013.01); C07H 13/04 (2013.01); C08G 63/06 (2013.01); C12P 7/26 (2013.01); C12P 7/62 (2013.01); Y02P 20/54 (2015.11);
Abstract

Novel compounds and compositions containing (R)-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making R-3-hydroxybutyrate derivatives also are disclosed. Exemplary methods employ a supercritical solvent, such as supercritical carbon dioxide, and employ a lipase catalyzed esterification or transesterification reaction to produce the (R)-3-hydroxybutyrate derivatives.


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