The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2022
Filed:
Dec. 25, 2017
Daiichi Sankyo Company, Limited, Tokyo, JP;
National University Corporation Kobe University, Hyogo, JP;
Kazumoto Iijima, Hyogo, JP;
Kandai Nozu, Hyogo, JP;
Akemi Shono, Hyogo, JP;
Makoto Koizumi, Tokyo, JP;
Yoshiyuki Onishi, Tokyo, JP;
Kiyosumi Takaishi, Tokyo, JP;
Tomomi Adachi, Tokyo, JP;
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, Hyogo, JP;
DAIICHI SANKYO COMPANY LIMITED, Tokyo, JP;
Abstract
The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).