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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11230698 B1

PDFFull Text
Date of Patent:
Jan. 25, 2022

Filed:

Jun. 21, 2019

Cytokine receptor genes and the use thereof to enhance therapy

Applicant:

Musc Foundation for Research Development, Charleston, SC (US);

Inventors:

Mark Rubinstein, James Island, SC (US);

David Cole, Mount Pleasant, SC (US);

Assignee:

MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, Charleston, SC (US);

Attorney:

Parker Highlander PLLC

Primary Examiner:

Robert M Kelly

Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61K 35/17 (2015.01); A61K 38/17 (2006.01); A61K 38/20 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0638 (2013.01); A61K 35/17 (2013.01); A61K 38/1793 (2013.01); A61K 38/20 (2013.01); A61K 38/2013 (2013.01); C07K 14/705 (2013.01); C07K 14/70521 (2013.01); C07K 14/715 (2013.01); C07K 14/7155 (2013.01); C12N 15/85 (2013.01); C12N 2510/00 (2013.01);
Abstract

Cells, such a T-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise IL-2 and/or IL-15 receptors having increased surface expression or signaling activity. Cells of the embodiments have a significant growth advantage in the presence of cytokines and can be used, e.g., for enhanced adoptive cell transfer therapies.

Find Patent Forward Citations

Rubinstein, Mark. (2022). Cytokine receptor genes and the use thereof to enhance therapy (U.S. Patent No. 11230698). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11230698

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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