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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11230697 B1

PDFFull Text
Date of Patent:
Jan. 25, 2022

Filed:

Jul. 26, 2018

Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals

Applicant:

Therapeutic Human Polyclonals Inc., Mountain View, CA (US);

Inventor:

Roland Buelow, Palo Alto, CA (US);

Assignee:

THERAPEUTIC HUMAN POLYCLONALS INC., Mountain View, CA (US);

Attorney:
Primary Examiner:

Shin Lin Chen

Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 15/63 (2006.01); C07H 21/04 (2006.01); C12N 5/0781 (2010.01); A01K 67/027 (2006.01); A61K 39/00 (2006.01); C07K 14/705 (2006.01); C09K 5/04 (2006.01); C12N 15/85 (2006.01); C12N 15/79 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0635 (2013.01); A01K 67/0278 (2013.01); A61K 39/00 (2013.01); C07K 14/70503 (2013.01); C09K 5/045 (2013.01); C12N 15/8509 (2013.01); A01K 67/0275 (2013.01); A01K 67/0276 (2013.01); A01K 2207/15 (2013.01); A01K 2217/052 (2013.01); A01K 2217/054 (2013.01); A01K 2217/072 (2013.01); A01K 2227/107 (2013.01); A01K 2267/01 (2013.01); C07H 21/04 (2013.01); C09K 2205/126 (2013.01); C12N 15/79 (2013.01); C12N 15/85 (2013.01); C12N 2510/02 (2013.01); C12N 2510/04 (2013.01); C12N 2517/02 (2013.01);
Abstract

The present invention describes transgenic animals with human(ized) immunoglobulin loci and transgenes encoding human(ized) Igα and/or Igβ sequences. Of particular interest are animals with transgenic heavy and light chain immunoglobulin loci capable of producing a diversified human(ized) antibody repertoire that have their endogenous production of Ig and/or endogenous Igα and/or Igβ sequences suppressed. Simultaneous expression of human(ized) immunoglobulin and human(ized) Igα and/or Igβ results in normal B-cell development, affinity maturation and efficient expression of human(ized) antibodies.

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