The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2022
Filed:
Oct. 10, 2018
Tilos Therapeutics, Inc., Lexington, MA (US);
Barbara S. Fox, Wayland, MA (US);
Randall Burton, Billerica, MA (US);
Stavros Kopsiaftis, West Roxbury, MA (US);
Xiufeng Song, Jamaica Plain, MA (US);
Patricia Rao, Acton, MA (US);
Kenneth J. Simon, Milton, MA (US);
Jessie M. English, Cambridge, MA (US);
Tilos Therapeutics, Inc., Cambridge, MA (US);
Abstract
Provided herein are antibodies which bind to latency-associated peptide (LAP) of TGF-β1 and are characterized by particular functional features, such as binding specifically to LAP-TGFβ1 on cells but not to LAP-TGFβ1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.