The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2022
Filed:
Feb. 03, 2017
Applicant:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Inventors:
Varda Rotter, Rehovot, IL;
Moshe Oren, Rehovot, IL;
Perry Tal, Rehovot, IL;
Shay Eizenberger, Rehovot, IL;
Avi Ben-Shimon, Rehovot, IL;
Assignee:
YEDA RESEARCH AND DEVELOPMENT CO. LTD., Rehovot, IL;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); A61P 35/00 (2006.01); A61K 9/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4746 (2013.01); A61K 9/0019 (2013.01); A61P 35/00 (2018.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); A61K 38/00 (2013.01);
Abstract
An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.