The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2022
Filed:
Oct. 13, 2016
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Michael Barish, Duarte, CA (US);
Christine E. Brown, Duarte, CA (US);
Stephen J. Forman, Duarte, CA (US);
Dongrui Wang, Duarte, CA (US);
Assignee:
City of Hope, Duarte, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 49/00 (2006.01); C07H 19/00 (2006.01); C07H 21/04 (2006.01); C07K 14/435 (2006.01); A61P 35/00 (2006.01); A61K 35/17 (2015.01); C07K 14/725 (2006.01); C07K 14/73 (2006.01); C07K 14/705 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 14/43522 (2013.01); A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70514 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C12N 5/0638 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/55 (2013.01); C12N 2510/00 (2013.01);
Abstract
Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain that includes chlorotoxin or a related toxin, or a variant of chlorotoxin or a related toxin, that binds to human glioma or other human tumor cells, a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.