The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 25, 2022

Filed:

Oct. 17, 2017
Applicants:

Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);

Triad National Security, Llc, Los Alamos, NM (US);

Inventors:

Dan H. Barouch, Brookline, MA (US);

Christine Bricault, Boston, MA (US);

Bette T. Korber, Los Alamos, NM (US);

Karina Yusim, Los Alamos, NM (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/21 (2006.01); A61K 39/00 (2006.01); C07K 16/10 (2006.01); A61K 39/12 (2006.01); C07K 14/005 (2006.01); A61K 47/68 (2017.01); A61P 31/18 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/21 (2013.01); A61K 47/6803 (2017.08); A61K 47/6841 (2017.08); A61P 31/18 (2018.01); C07K 16/1045 (2013.01); A61K 2039/545 (2013.01); C07K 2317/24 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16134 (2013.01);
Abstract

The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).


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