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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11230554 B1

PDFFull Text
Date of Patent:
Jan. 25, 2022

Filed:

Mar. 21, 2019

Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds

Applicant:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Rajinder Singh, Belmont, CA (US);

Ankush Argade, Foster City, CA (US);

Hui Li, Santa Clara, CA (US);

Somasekhar Bhamidipati, Foster City, CA (US);

David Carroll, San Francisco, CA (US);

Catherine Sylvain, San Mateo, CA (US);

Jeffrey Clough, Redwood City, CA (US);

Holger Keim, Irvine, CA (US);

Assignee:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorney:

Klarquist Sparkman, LLP

Primary Examiner:

Tracy Vivlemore

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
C07D 498/04 (2006.01); A61K 31/506 (2006.01); A61K 31/541 (2006.01); C07D 403/14 (2006.01); C07D 498/02 (2006.01); A61K 31/538 (2006.01); A61P 19/02 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 498/06 (2006.01);
U.S. Cl.
CPC ...
C07D 498/04 (2013.01); A61K 31/506 (2013.01); A61K 31/538 (2013.01); A61K 31/541 (2013.01); A61P 19/02 (2018.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 498/02 (2013.01); C07D 498/06 (2013.01);
Abstract

The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lupus erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

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