The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 25, 2022

Filed:

May. 16, 2018
Applicants:

University of Virginia Patent Foundation, Charlottesville, VA (US);

The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);

Inventors:

Kevin S. Lee, Charlottesville, VA (US);

Edward H. Bertram, Charlottesville, VA (US);

Max Wintermark, Menlo Park, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61N 7/00 (2006.01); G01R 33/50 (2006.01); G01R 33/48 (2006.01); A61B 5/055 (2006.01); A61M 37/00 (2006.01); A61B 5/00 (2006.01); G01R 33/56 (2006.01); A61B 90/00 (2016.01); A61B 34/00 (2016.01);
U.S. Cl.
CPC ...
A61N 7/00 (2013.01); A61B 5/0036 (2018.08); A61B 5/055 (2013.01); A61B 5/7485 (2013.01); A61M 37/0092 (2013.01); G01R 33/4808 (2013.01); G01R 33/4814 (2013.01); G01R 33/50 (2013.01); A61B 5/0042 (2013.01); A61B 5/4839 (2013.01); A61B 34/25 (2016.02); A61B 2090/374 (2016.02); A61B 2576/026 (2013.01); A61M 2205/05 (2013.01); A61M 2205/058 (2013.01); A61M 2210/0693 (2013.01); A61N 2007/003 (2013.01); A61N 2007/0039 (2013.01); A61N 2007/0095 (2013.01); G01R 33/5601 (2013.01);
Abstract

Methods and systems are described for producing non-invasive and targeted neuronal lesions using magnetic resonance and acoustic energy. Imaging data corresponding to a region of interest is obtained, the region of interest within an imaging subject. Information indicative of a target region within the region of interest is received from the obtained imaging data. Focused acoustic energy directed to the target region within the region of interest is generated to disrupt a barrier between a therapeutic agent and parenchymal tissue in response to insonification by the focused acoustic energy, the therapeutic agent comprising a neurotoxin and microbubbles.


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