The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2022
Filed:
Sep. 25, 2020
Applicant:
Immunogen, Inc., Waltham, MA (US);
Inventors:
Ravi V. J. Chari, Newton, MA (US);
Wayne C. Widdison, Belmont, MA (US);
Wei Li, Acton, MA (US);
David P. Pleynet, Newton, MA (US);
Assignee:
IMMUNOGEN, INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4745 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 39/395 (2006.01); C07D 491/22 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4745 (2013.01); A61K 39/3955 (2013.01); A61K 47/6803 (2017.08); A61P 35/00 (2018.01); C07D 491/22 (2013.01);
Abstract
Disclosed herein are novel cytotoxic compounds, and cytotoxic conjugates comprising these cytotoxic compounds and cell-binding agents. More specifically, this disclosure relates to novel camptothecin derivatives thereof, intermediates thereof, conjugates thereof, and pharmaceutically acceptable salts thereof, which are useful as medicaments, in particular as anti-proliferative agents (anticancer agents).