The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 25, 2022

Filed:

Dec. 19, 2018
Applicant:

Nova Southeastern University, Fort Lauderdale, FL (US);

Inventors:

Mutasem Rawas-Qalaji, Fort Lauderdale, FL (US);

Ousama Rachid, Winnipeg, CA;

Keith Simons, Winnipeg, CA;

Estelle Simons, Winnipeg, CA;

Assignee:

Nova Southeastern University, Fort Lauderdale, FL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/56 (2006.01); A61K 31/137 (2006.01); A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 31/00 (2006.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01);
U.S. Cl.
CPC ...
A61K 31/137 (2013.01); A61K 9/006 (2013.01); A61K 9/0056 (2013.01); A61K 9/14 (2013.01); A61K 31/00 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01);
Abstract

The invention provides compositions including epinephrine fine particles, including epinephrine nanoparticles or nanocrystals and epinephrine microparticles or microcrystals, and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine fine particles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required.


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