The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2022
Filed:
Jan. 09, 2017
Western University of Health Sciences, Pomona, CA (US);
Tesorx Pharma, Llc, Menlo Park, CA (US);
Guru V. Betageri, Chino Hills, CA (US);
Natarajan Venkatesan, Diamond Bar, CA (US);
Michael G. Oefelein, Bakersfield, CA (US);
Ramachandran Thirucote, Atherton, CA (US);
Nitin Kumar Swarnakar, Tarrytown, NY (US);
Teresa Hong, El Monte, CA (US);
WESTERN UNIVERSITY OF HEALTH SCIENCES, Pomona, CA (US);
TESORX PHARMA, LLC, Menlo Park, CA (US);
Abstract
Compositions and methods for making and using proliposomal and liposomal formulations of chemotherapeutic agents are disclosed. The proliposomal and liposomal formulations of chemotherapeutics, as well as medicaments and dosage forms that include such formulations, can be used with treatment regimens for bladder cancer and urothelial cancer. Hence, the formulations, medicaments, and dosage forms of the invention are suitable to treat bladder cancers by intravesical administration and to treat urothelial cancers. The formulations according to the invention include (a) a taxane (e.g., paclitaxel, docetaxel) or cisplatin, (b) a first phospholipid, dipalmitoyl phosphatidylcholine (DMPC), and (c) a second phospholipid, dimyrsityl phosphatidyl glycerol sodium (DMPG). The proliposomal formulations form liposomes upon contact with an aqueous vehicle.