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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11225468 B1

PDFFull Text
Date of Patent:
Jan. 18, 2022

Filed:

Nov. 22, 2019

Nicotine salts, co-crystals, and salt co-crystal complexes

Applicant:

R.j. Reynolds Tobacco Company, Winston-Salem, NC (US);

Inventors:

Gary M. Dull, Lewisville, NC (US);

Susana del Rio Gancedo, Cambridge, GB;

Judit Galcera Julia, Sant Just Desvern, ES;

Assignee:

R.J. Reynolds Tobacco Company, Winston-Salem, NC (US);

Attorney:

Womble Bond Dickinson (US) LLP

Primary Examiner:

Heidi Reese

Int. Cl.
CPC ...
C07D 401/04 (2006.01); A61K 9/00 (2006.01); C07C 65/11 (2006.01); A24B 15/38 (2006.01); C07C 65/03 (2006.01); A24B 13/00 (2006.01); A24D 1/20 (2020.01); C07C 59/235 (2006.01); C07D 213/82 (2006.01); C07C 59/40 (2006.01); C07C 59/245 (2006.01); C07D 239/557 (2006.01); A61M 15/06 (2006.01); A61M 11/04 (2006.01); A24F 40/10 (2020.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A24B 13/00 (2013.01); A24B 15/38 (2013.01); A24D 1/20 (2020.01); A61K 9/0056 (2013.01); C07C 59/235 (2013.01); C07C 59/245 (2013.01); C07C 59/40 (2013.01); C07C 65/03 (2013.01); C07C 65/11 (2013.01); C07D 213/82 (2013.01); C07D 239/557 (2013.01); A24F 40/10 (2020.01); A61M 11/042 (2014.02); A61M 15/06 (2013.01); A61M 2205/8206 (2013.01); C07B 2200/13 (2013.01);
Abstract

The invention provides certain nicotine salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, certain nicotine salt-co-crystals are described, including nicotine and two different coformers. The invention further provides methods of preparation and characterization of nicotine salts, co-crystals, and salt co-crystals. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and/or salt co-crystals are also provided.

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